🌿 Dermveda vs. Leading Hemorrhoid Creams
Compare Ingredients, Benefits, and Safety
Side effects and efficacy supported by PubMed clinical studies and leading medical sources1-14
| Feature | Dermveda 🌱 | Preparation H ⚡ | Anusol HC 💊 | DrFormulas 🌬️ |
|---|---|---|---|---|
| Active Ingredients | 🦠 Sulfur11,14, 🌼 Curcumin12, 🍃 Aloe, 🌿 Peppermint13 | ⚡ Phenylephrine, 🛡️ Pramoxine | 💊 Hydrocortisone, 🧪 Zinc Oxide | 🌬️ Menthol, 🌲 Camphor |
| Best For | 🦠 Inflammation, Pain, Swelling, Infection-prone cases11,14 | ⚡ Pain/swelling relief1,3,4,5,6,7 | 💊 Inflammation2,8,9,10 | 🩸 Thrombosed hemorrhoids |
| Side Effects | 🌿 Herbal sensitivity (rare)13 🦠 No serious adverse events with sulfur in RCT14 | ⚠️ Allergic reaction, ↑BP, rebound swelling, rectal pain, irritation1,3,4,5,6,7 | ⚠️ Skin thinning, burning, itching, dryness, adrenal suppression, infection risk2,8,9,10 | 🔥 Burning sensation |
| Long-Term Use | ✅ Safe (no steroids or vasoconstrictors) | ⏳ ≤7 days1,3,4,5,6,7 | ⏳ ≤1 week2,8,9,10 | ❓ Not specified |
| Infection Prevention | 🦠 Yes (sulfur)11,14 | ❌ No | 🧪 Minimal (zinc) | ❌ No |
References
1 Drugs.com. (2023). Phenylephrine Topical Side Effects.
2 WebMD. (2023). Hydrocortisone Rectal Side Effects.
3 Drugs.com. (2025). Phenylephrine rectal Uses, Side Effects & Warnings.
4 Drugs.com. (2024). Phenylephrine: Uses, Dosage, Side Effects, Warnings.
5 Drugs.com. (2000). Glycerin / Petrolatum / Phenylephrine / Pramoxine Topical Side Effects.
6 Drugs.com. (2023). Phenylephrine Patient Tips.
7 WebMD. (2025). Phenylephrine-Witch Hazel Gel - Uses, Side Effects, and More.
8 WebMD. (2023). Hydrocortisone Rectal Side Effects.
9 WebMD. (2023). Hydrocortone Acetate rectal - Uses, Side Effects, and More.
10 WebMD. (2023). Anusol-HC 2.5 % Rectal Cream - Uses, Side Effects, and More.
11 PubMed. (2022). Sulfur: Antimicrobial activities in dermatology.
12 PubMed. (2023). Curcumin: Antioxidant and anti-inflammatory effects.
13 PubMed. (2024). Peppermint oil in gastroenterology.
14 PubMed. (2024). Double-Blind, Randomized, Placebo-Controlled Trial of Individualized Homeopathic Medicines (IHMs) for Hemorrhoids: In a 2024 RCT (n=140), IHMs-most frequently sulfur-significantly reduced hemorrhoid symptom severity and improved quality of life versus placebo, with no serious adverse events reported.
Dr. Jen Haley M.D.
Board Certified Dermatologist.
Dr.Jen Haley, a Board-Certified Dermatologist with over 20 years of expertise in medical, surgical, and cosmetic dermatology, is deeply committed to a holistic approach that integrates skin health, fitness, nutrition, and environmental natural wellness. Dr. Haley helps clarify the important difference sbetween fungal acne (Malassezia folliculitis) and traditional regular bacterial acne, emphasizing the need for targeted treatments. Dermveda harnesses advanced skin science combined with natural extracts to support skin conditions like fungal acne, seborrheic dermatitis, and psoriasis, offering soothing, effective relief rooted in both nature and dermatological innovation.
How Dermveda Hemorrhoids Cream Is Different:
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Comprehensive Symptom and Complication Relief: While most hemorrhoid creams focus only on temporary symptom relief-such as reducing pain, swelling, or itching-Dermveda goes further by addressing the root causes that can lead to complications.
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Most conventional creams use ingredients like phenylephrine (a vasoconstrictor) or hydrocortisone (a steroid) for short-term swelling and itching relief, but these can cause side effects like skin thinning, rebound swelling, or irritation with prolonged use.
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Prevents Secondary Infection: Sulfur, a key ingredient in Dermveda, provides broad-spectrum antimicrobial protection. This helps prevent bacterial or fungal infections-a risk with broken or irritated skin around hemorrhoids-setting Dermveda apart from creams that only soothe symptoms
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Promotes Natural Healing: Curcumin, the active compound in turmeric, inhibits COX-2 and other inflammatory pathways, reducing swelling, redness, and discomfort while supporting tissue repair and healing. This mechanism is steroid-free, making it safe for sensitive skin and long-term use.
Dermveda combines sulfur’s proven antimicrobial action with curcumin’s advanced anti-inflammatory properties, promoting both rapid relief and long-term skin health
🧬How Dermveda’s Ingredient Synergy Works
Curcumin (from Turmeric):
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Functions as an antioxidant, scavenging free radicals and reducing oxidative stress that contributes to tissue damage.
Sulfur:
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Provides broad-spectrum antimicrobial activity, helping to prevent secondary infections in damaged or inflamed perianal tissue.
Aloe Vera:
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Delivers anti-inflammatory and wound-healing effects by inhibiting cyclooxygenase and reducing prostaglandin E2, as well as blocking bradykinin and histamine pathways.
Peppermint:
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Offers a natural cooling and soothing effect by activating cold-sensitive receptors (TRPM8) in the skin, which helps relieve itching and discomfort.
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Reduces the urge to scratch, helping to preserve the skin barrier and prevent further irritation or bacterial entry.
🌸 Symptom Relief: How Dermveda Addresses the Full Spectrum of Hemorrhoids symptoms
Synergistic Mechanisms
1. Curcumin and sulfur together provide enhanced antibacterial action: Curcumin increases bacterial membrane permeability by activating mechano sensitive channels (MscL), allowing sulfur to penetrate and disrupt bacterial metabolism more effectively. This dual action amplifies their antimicrobial efficacy against pathogens like Staphylococcusaureus and Pseudomonas aeruginosa.
2. Curcumin and aloe both suppresskey inflammatory mediators: Curcumin inhibits NF-κB, COX-2, and TNF-α pathways, while aloe vera blocks prostaglandin E2 and histamine release. Together, they reduce inflammation at both cellular and tissue levels, accelerating wound repair.
3. Aloe and peppermint work in tandem to soothe, hydrate, and cool the skin: Aloe vera’s mucopolysaccharides hydrate and stimulate fibroblast activity, while peppermint activates TRPM8 receptors, providing immediate cooling relief. This combination reduces itching, irritation, and supports barrier repair.
4. Overall synergy results: This multi-target approach delivers faster symptom relief (via anti-inflammatory and cooling effects), reduced infection risk (via enhanced antimicrobial action), and accelerated tissue repair (via fibroblast stimulation and collagen synthesis) compared to single-ingredient or conventional steroid/vasoconstrictor creams.
| ✅ Do | ❌ Don't |
|---|---|
| Clean and dry the affected area before applying Dermveda Cream | Don't apply on open wounds or bleeding hemorrhoids |
| Use a pea-sized amount for each application | Don't overuse or slather large amounts |
| Store the cream in a cool, dry place | Don't expose the jar to direct sunlight or heat |
| Wash hands before and after applying | Don't touch eyes or mouth after application |
| Perform a patch test if you have sensitive skin | Don't continue use if irritation or rash occurs |
| Apply after bowel movements and before bedtime | Don't skip doses if symptoms persist |
| Consult a healthcare provider if symptoms worsen | Don't use in place of medical advice for severe cases |
Frequently Asked Questions
Dermveda Hemorrhoid Cream – Frequently Asked Questions
Dermveda Hemorrhoid Cream is a natural, steroid-free topical formula designed to relieve the symptoms of hemorrhoids, including itching, burning, swelling, and discomfort. It combines antimicrobial sulfur, anti-inflammatory curcumin, soothing aloe vera, and cooling peppermint for multi-symptom relief and infection prevention.
Dermveda works by:
• Reducing inflammation and swelling with curcumin, a natural COX-2 inhibitor.
• Preventing infection with sulfur’s proven antimicrobial properties.
• Soothing and cooling irritated skin using aloe vera and peppermint.
• Supporting skin repair for faster recovery from hemorrhoidal irritation.
Clean and gently dry the affected area before application.
Apply a pea-sized amount of cream externally to the affected area up to 3-4 times daily, especially after bowel movements and before bed.
Wash hands thoroughly after use.
For external use only; do not insert into the rectum unless directed by a doctor.
Yes. Dermveda is free from steroids and vasoconstrictors (like hydrocortisone or phenylephrine), making it suitable for daily and long-term use without the risk of skin thinning, rebound swelling, or systemic side effects often associated with conventional creams.
Dermveda’s formula is based on gentle, natural ingredients and does not contain steroids or harsh chemicals. However, as with any topical product, pregnant or breastfeeding individuals should consult their healthcare provider before use.
• Antimicrobial protection: Sulfur helps prevent secondary infections, a risk with broken or irritated skin.
• Natural anti-inflammatory action: Curcumin reduces swelling and discomfort without steroids.
• Gentle and soothing: Aloe vera and peppermint calm sensitive skin and provide cooling relief.
• No parabens, alcohol, or synthetic fragrances: Safe for sensitive skin and daily use.
No topical cream can cure hemorrhoids, but Dermveda is formulated to provide fast, effective relief from symptoms and support the body’s natural healing process. For persistent, severe, or bleeding hemorrhoids, consult a healthcare professional for further evaluation and treatment options.
Dermveda is available online through our official website, Amazon, and select pharmacies.
Store in a cool, dry place away from direct sunlight. Keep the cap tightly closed after each use.
The duration of hemorrhoids varies by type and severity. Small hemorrhoids often resolve within a few days to a week. Larger or more severe hemorrhoids may take several weeks to heal, especially if risk factors like constipation or straining are not addressed. Thrombosed hemorrhoids (with a blood clot) can last two to three weeks or longer. If your symptoms persist beyond a week or worsen, consult a healthcare provider.1–10
Yes, most hemorrhoids go away on their own, especially smaller ones. This process usually takes a few days to a week as swelling decreases. However, some hemorrhoids may not resolve without treatment, especially if they are large, prolapsed, or thrombosed. Preventing recurrence involves addressing causes such as constipation, straining, and low fiber intake.3–10